Soluble CD163, a Product of Monocyte/Macrophage Activation, Is Inversely Associated with Haemoglobin Levels in Placental Malaria

CLL Chua; GV Brown; JA Hamilton; ME Molyneux; SJ Rogerson; P Boeuf

Journal article

Soluble CD163, a Product of Monocyte/Macrophage Activation, Is Inversely Associated with Haemoglobin Levels in Placental Malaria

CLL Chua, GV Brown, JA Hamilton, ME Molyneux, SJ Rogerson, P Boeuf

Plos One | PUBLIC LIBRARY SCIENCE | Published : 2013

DOI: 10.1371/journal.pone.0064127

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Abstract

In Plasmodium falciparum malaria, activation of monocytes and macrophages (monocytes/macrophages) can result in the production of various inflammatory mediators that contribute to immunopathology. Soluble CD163 (sCD163) is a specific marker of monocyte/macrophage activation typically found at increased levels during various inflammatory conditions and can be associated with poor clinical outcomes. To better understand the relationships between levels of sCD163 and clinical parameters in women with placental malaria, we measured plasma sCD163 levels in maternal peripheral and placental blood compartments at delivery and determined their correlations with birth weight and maternal haemoglobin ..

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University of Melbourne Researchers

Graham Brown Author

John Hamilton Author

Stephen Rogerson Author

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Grants

Awarded by Wellcome Trust Senior Overseas Fellowship

Funding Acknowledgements

Sample collection was funded by a Wellcome Trust Senior Overseas Fellowship to SJR (ref 063215). CLLC was supported by a PhD scholarship from the Nossal Institute for Global Health, Melbourne, Australia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.